Raquel A. Riquelme

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High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep.

Emilio A. Herrera, Victor M Pulgar, +9 authors Aníbal J. Llanos
American journal of physiology. Regulatory…
2007

Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze… (More)

Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level

Emilio A. Herrera, Raquel A. Riquelme, +7 authors Aníbal J. Llanos
American journal of physiology. Regulatory…
2010

We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms… (More)

Sildenafil Reverses Hypoxic Pulmonary Hypertension in Highland and Lowland Newborn Sheep

Emilio A. Herrera, Germán Ebensperger, +6 authors Aníbal J. Llanos
Pediatric Research
2008

Perinatal exposure to chronic hypoxia induces sustained hypertension and structural and functional changes in the pulmonary vascular bed. We hypothesized that highland newborn lambs (HLNB, 3600 m)… (More)

Evolving in thin air--lessons from the llama fetus in the altiplano.

Aníbal J. Llanos, Raquel A. Riquelme, +11 authors Mark A. Hanson
Respiratory physiology & neurobiology
2007

Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all… (More)

The fetal llama versus the fetal sheep: different strategies to withstand hypoxia.

Aníbal J. Llanos, Raquel A. Riquelme, +8 authors Dino A Giussani
High altitude medicine & biology
2003

The pregnant llama (Lama glama) has walked for millions of years through the thin oxygen trail of the Andean altiplano. We hypothesize that a pool of genes has been selected in the llama that express… (More)

Fetal brain hypometabolism during prolonged hypoxaemia in the llama.

Germán Ebensperger, Renato Ebensperger, +7 authors Roberto V Reyes
The Journal of physiology
2005

In this study we looked for additional evidence to support the hypothesis that fetal llama reacts to hypoxaemia with adaptive brain hypometabolism. We determined fetal llama brain temperature, Na(+)… (More)

Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano.

Emilio A. Herrera, Roberto V Reyes, +13 authors Aníbal J. Llanos
Cardiovascular research
2008

AIMS To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. METHODS AND RESULTS We used neonatal… (More)

Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs.

Daniela B Parrau, Germán Ebensperger, +12 authors Roberto V Reyes
American journal of physiology. Lung cellular and…
2013

We determined whether store-operated channels (SOC) are involved in neonatal pulmonary artery function under conditions of acute and chronic hypoxia, using newborn sheep gestated and born either at… (More)

Chemoreflex and endocrine components of cardiovascular responses to acute hypoxemia in the llama fetus.

Dino A Giussani, Raquel A. Riquelme, +5 authors Alvaro Llanos
The American journal of physiology
1996

We tested the hypothesis that the llama fetus has a blunted cardiovascular chemoreflex response to hypoxemia by investigating the effects of acute hypoxemia on perfusion pressure, heart rate, and the… (More)

Fetal and postnatal pulmonary circulation in the Alto Andino.

Aníbal J. Llanos, Germán Ebensperger, +8 authors Raquel A. Riquelme
Placenta
2011

Lowland mammals at high altitude constrict the pulmonary vessels, augmenting vascular resistance and developing pulmonary arterial hypertension. In contrast, highland mammals, like the llama, do not… (More)

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