Raphael Sivan

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A model of the sarcomeric control of contraction at various loading conditions has to maintain three cardinal features: stability, controllability (where the output can be controlled by the input), and observability (where the output reflects the effects of all the state variables). The suggested model of the sarcomere couples calcium kinetics with(More)
Analysis of the hystereses in the force-length relationship at constant Ca(2+) concentration and in the force-calcium relationship at constant sarcomere length (SL) provides insight into the mechanisms that control cross-bridge (XB) recruitment. The hystereses are related here to two mechanisms that regulate the number of strong XBs: the cooperativity,(More)
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