Raphael Clifford

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We describe here a system for the rapid identification, assay development, and characterization of gene-based single nucleotide polymorphisms (SNPs). This system couples informatics tools that mine candidate SNPs from public expressed sequence tag resources and automatically designs assay reagents with detection by a chip-based matrix-assisted laser(More)
SNPs (Single-Nucleotide Polymorphisms), the most common DNA variant in humans, represent a valuable resource for the genetic analysis of cancer and other illnesses. These markers may be used in a variety of ways to investigate the genetic underpinnings of disease. In gene-based studies, the correlations between allelic variants of genes of interest and(More)
With the rapid growth of Internet, E-mail, with its convenient and efficient characteristics, has become an important means of communication in people's life. It reduces the cost of communication. It comes with Spam. Spam emails, also known as 'junk e-mails', are unsolicited one's sent in bulk with hidden or forged identity of the(More)
intrinsic noise (16) decays rapidly: t intrinsic G 10 min ¡ t corr (Fig. 4E). Thus, the observed slow fluctuations do not result from intrinsic noise; they represent noise extrinsic to CFP expression (see supporting online text). The concentration of a stable cellular factor would be expected to fluctuate with a time scale of the cell cycle period (7, 10).(More)
We show tight bounds for both online integer multiplication and convolution in the cell-probe model with word size w. For the multiplication problem, one pair of digits, each from one of two n digit numbers that are to be multiplied, is given as input at step i. The online algorithm outputs a single new digit from the product of the numbers before step i +(More)
We study the classical complexity of the exact Boson Sampling problem where the objective is to produce provably correct random samples from a particular quantum mechanical distribution. The computational framework was proposed by Aaronson and Arkhipov in 2011 as an attainable demonstration of `quantum supremacy', that is a practical quantum computing(More)
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