Raphaël Trouillon

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Magnetic micro- and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quantification of a sample's analyte concentration have been among the most sensitive and have allowed(More)
We describe the concept of magnetic particle-scanning for on-chip detection of biomolecules: a magnetic particle, carrying a low number of antigens (Ag's) (down to a single molecule), is transported by hydrodynamic forces and is subjected to successive stochastic reorientations in an engineered magnetic energy landscape. The latter consists of a pattern of(More)
We demonstrate a method to determine the Brownian motion and the diffusion coefficient of a nanoparticle in water in a plane that is parallel to a solid boundary and as function of the distance normal to that boundary by using an optical tweezers instrument. A solution of 190 nm-diameter fluorescent polystyrene nanoparticles in de-ionized (DI) water is(More)
1 Member of the ISE The diffusion layer is a critical factor affecting the temporal response of electrochemical devices. In this article, we have investigated the effect of the relaxation of the diffusion layer during the potentiodynamic sensing of ferrocenemethanol (FcMeOH) in microchannels and compared these results to amperometry. First, the effect of(More)
A straightforward and general way for monitoring chemical reactions is via their thermal signature. Such approach requires however an experimental setup with a high thermal stability that simultaneously allows time‐resolved heat detection with high sensitivity. We present a nanocalorimetric platform for accurate thermochemical studies of (bio‐)chemical(More)
The time responses of two electrochemical methods, amperometry (AMP) and cyclic voltammetry (CV), used in a microchannel to detect the concentration variations of an outer-sphere redox species were compared. Overall, our results show that the temporal resolution of AMP is superior to the one of CV. As no secondary reaction (formation of chemical bounds,(More)
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