Raphaël Guattéo

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Reliable detection of Coxiella burnetii is a critical point for the control of the spread of this zoonotic disease (Q fever), ruminants being considered as the main source for human infection as confirmed by the recent human outbreak in the Netherlands since 2007. Considering both public and animal health, providing consolidated prevalence data could be(More)
Q fever is an ubiquitous zoonosis caused by an resistant intracellular bacterium, Coxiella burnetii. In certain areas, Q fever can be a severe public health problem, and awareness of the disease must be promoted worldwide. Nevertheless, knowledge of Coxiella burnetii remains limited to this day. Its resistant (intracellular and environmental) and infectious(More)
While shedding routes of Coxiella burnetii are identified, the characteristics of Coxiella shedding are still widely unknown, especially in dairy cattle. However, this information is crucial to assess the natural course of Coxiella burnetii infection within a herd and then to elaborate strategies to limit the risks of transmission between animals and to(More)
Reliable detection of Coxiella burnetii shedders is a critical point for the control of the spread of this bacterium among animals and from animals to humans. Coxiella burnetii is shed by ruminants mainly by birth products (placenta, birth fluids), but may also be shed by vaginal mucus, milk, and faeces, urine and semen. However, the informative value of(More)
The objective of this study was to estimate the association between digital dermatitis (DD) lesions and test-day milk yield (TDY) in dairy cows, taking into account the severity of the lesions. Data were collected for 6 mo on 47 French dairy farms endemically affected by DD and involved in a clinical trial aiming to assess the effectiveness of collective(More)
The purpose of this study was to concurrently estimate the effect of different digital dermatitis (DD) treatment regimens and herd management practices on the occurrence of a new DD lesion. A controlled clinical trial was conducted and involved 4678 dairy cows from 52 French dairy farms where DD was endemic. Farms were allocated by minimisation to one of 4(More)
The main objective of this study was to assess the efficacy of a monovalent inactivated vaccine containing phase I Coxiella burnetii to prevent Coxiella shedding in susceptible dairy cows within infected herds in comparison to a placebo. A total of 336 dairy cows and heifers, from six spontaneously infected herds, were followed over a 1-year period. Before(More)
Thirty-seven bulk tank milk (BTM) and individual milk samples of all contributing cows were tested for Coxiella burnetii detection by a real-time PCR assay and used to assess the relationship between the BTM PCR-response and (i) the within-herd prevalence of milk-shedder cows and (ii) the proportion of heavy milk-shedder cows. The within-herd prevalence of(More)
The diagnosis of digital dermatitis (DD) in cows is crucial for researchers to evaluate the effectiveness of control measures. The objective of this study was to evaluate intra- and inter-observer agreement and accuracy of a simple method to score DD lesions that is based on the inspection of cleaned feet in the milking parlor with a swiveling mirror and a(More)
To describe both shedding and serological patterns following abortions detected as being associated with Coxiella burnetii (Cb), 24 cows experiencing an abortion due to Cb were followed over a one month period. Samples taken on the day of abortion (D0) were followed 3-fold by weekly samplings from day 14 (D14) to D28 after the abortion. Milk and vaginal(More)