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OBJECTIVE Up to 70% of typical meningiomas demonstrate allelic loss at chromosome 22q. Allelic loss at additional chromosomal loci is associated with atypia and anaplasia in meningiomas. The pattern of allelic loss or loss of heterozygosity (LOH) follows a nonrandom, multistep pattern. METHODS All surgical meningioma samples obtained from 1991 to 1992 at(More)
BACKGROUND The bone morphogenetic protein (BMP) signalling pathway is crucial in a number of developmental processes and is critical in the formation of variety of craniofacial elements including cranial neural crest, facial primordium, tooth, lip and palate. It is an important mediator in regulation of lip and palate fusion, cartilage and bone formation.(More)
The objective of this study is to identify association of GSTM1 and GSTT1 null gene polymorphisms with risk of cancer in defined populations in South India with histologically confirmed pre-malignant laryngeal lesions. Different parameters were taken into consideration and a demographic risk profile was defined as reported from a hospital-based cancer(More)
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