Ranjith Kumar

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Hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses multiple enzyme activities. The N-terminal one-third of NS3 primarily functions as a serine protease, while the remaining two-thirds of NS3 serve as a helicase and nucleoside triphosphatase. Whether the multiple enzyme activities of NS3 are functionally interdependent and/or modulated by other(More)
The supply voltage to threshold voltage ratio is reduced with each new technology generation. The gate overdrive variation with temperature plays an increasingly important role in determining the speed characteristics of CMOS integrated circuits. The temperature-dependent propagation delay characteristics, as shown in this brief, will experience a complete(More)
Temperature fluctuations alter threshold voltage, carrier mobility, and saturation velocity of a MOSFET. Temperature fluctuation induced variations in individual device parameters have unique effects on MOSFET drain current. Device parameters that characterize the variations in MOSFET current due to temperature fluctuations are identified in this paper for(More)
integrated circuit and fluctuations in the environmental temperature can cause significant variations in the die temperature [1]. Fluctuations in the die temperature affect the device characteristics thereby varying the performance of an integrated circuit. In this paper, the supply and threshold voltage optimization techniques to achieve temperature(More)
Computer-aided design (CAD) tools are frequently employed to verify the design objectives before the fabrication of an integrated circuit. An important circuit parameter that requires accurate characterization is the power consumption due to the strict constraints on the acceptable power envelope of integrated systems. Circuit simulators typically provide(More)
Circuits optimized for minimum energy consumption operate typically in the subthreshold regime with ultra-low power-supply voltages. Speed of a subthreshold logic circuit is enhanced with an increase in the die temperature. The excessive timing slack observed in the clock period of subthreshold logic circuits at elevated temperatures provides opportunities(More)
Operating an integrated circuit at the prescribed nominal supply voltage is not preferable for reliable circuit operation under temperature fluctuations. A design methodology based on optimizing the supply voltage for temperature variation insensitive circuit performance is presented in this paper. Circuits display temperature variation insensitive delay(More)
INTRODUCTION Calcium hydroxide is widely used as an intracanal medicament in endodontics. Its therapeutic effects depend on the dissociation of calcium hydroxide into calcium and hydroxyl ions, which, in turn, depends on the vehicle used. The purpose of this in vitro study was to evaluate the sustained release of calcium ions and the pH change of calcium(More)
Diabetes mellitus, in simple terms called as diabetes, is a metabolic disease, where a person is affected with high blood glucose level. Diabetes is a metabolic disorder caused due to the failure of body to produce insulin or to properly utilize insulin. This condition arises when the body does not produce enough insulin, or because the cells do not respond(More)
AIM The purpose of this study was to investigate and compare the linear dimensional accuracy of denture bases processed with the conventional heat-polymerization technique and the Rafael and Saide (RS) tension system, taking a multidirectional approach. MATERIALS AND METHODS Twenty standard edentulous maxillary casts were randomly assigned into two(More)