Ranjeet Prasad Dash

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The chiral conversion exhibited by several racemates of non-steroidal anti-inflammatory drugs, such as ibuprofen, ketoprofen, fenoprofen, etc., is a topic of great interest [1, 2]. In this context, Lorier et al. have recently performed an interesting clinical study in healthy male and female subjects who were dosed with two different formulations of(More)
The occurrence of efflux mechanisms via Permeability-glycoprotein (P-gp) recognized as an important physiological process impedes drug entry or transport across membranes into tissues. In some instances, either low oral bioavailability or lack of brain penetration has been attributed to P-gp mediated efflux activity. Therefore, the objective of development(More)
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) where the communication ability of nerve cells in the brain and spinal cord with each other gets impaired. Some current findings suggest the role of glutamate excitotoxicity in the development and progression of MS. An excess release of glutamate leads to the(More)
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