Ranjana Unnithan

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The negative-feedback actions of corticosterone (CORT) depend on both phasic and tonic CORT secretion patterns to regulate hypothalamic-pituitary-adrenal (HPA) axis activity. How these two different CORT secretion pattens influence specific intracellular signal transduction pathway activity within the cellular elements of the HPA axis has not been(More)
The design for a simple, low-cost aerosol generation system for rodent inhalation studies is described here. This system is appropriate for low biohazard-level agents. In this study, two biosafety level 2 agents, Pasturella pneumotropica and Pseudomonas aeruginosa, were tested successfully. This system was also used to immunize mice and guinea pigs in(More)
Blood serum collected from female mice treated with oestrogen and progesterone was assayed for its ability to induce acrosome degeneration. The maximum activity was found in serum obtained from females treated with 1.0 mug oestrogen/day for 5 days. Lower doses did not produce any significant difference from the control group. Blood serum from pregnant or(More)