Rania A. Mekary

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For a fixed amount of time engaged in physical activity, activity choice may affect body weight differently depending partly on other activities' displacement. Typical models used to evaluate effects of physical activity on body weight do not directly address these substitutions. An isotemporal substitution paradigm was developed as a new analytic model to(More)
BACKGROUND Among adults, skipping meals is associated with excess body weight, hypertension, insulin resistance, and elevated fasting lipid concentrations. However, it remains unknown whether specific eating habits regardless of dietary composition influence coronary heart disease (CHD) risk. The objective of this study was to prospectively examine eating(More)
BACKGROUND It is well established that aerobic physical activity can lower the risk of type 2 diabetes (T2D), but whether muscle-strengthening activities are beneficial for the prevention of T2D is unclear. This study examined the association of muscle-strengthening activities with the risk of T2D in women. METHODS AND FINDINGS We prospectively followed(More)
Although physical activity (PA) has been inversely associated with depressive symptoms, it is not clear whether regular PA and television watching are associated with clinical depression risk. The authors conducted a prospective analysis involving 49,821 US women from the Nurses' Health Study who were free from depressive symptoms at baseline (1996).(More)
To examine the association between total antioxidant capacity (TAC) intake and colorectal cancer incidence. TAC intake was assessed in 1986 and every 4 years thereafter in the Health Professionals Follow-up Study, a prospective cohort study of 47,339 men. Between 1986 and 2004, 952 colorectal cancer cases were diagnosed. Cox proportional hazards regression(More)
BACKGROUND Delayed symptomatic hyponatremia (DSH) is a known complication of transsphenoidal surgery that can lead to prolonged hospital stay, readmission, and in rare cases, death. Many potential predictors for development of DSH have been investigated. A better understanding of DSH risk can lead to better patient outcomes. We performed a systematic review(More)
BACKGROUND To our knowledge, research has not been conducted on bicycle riding and weight control in comparison with walking. Our objective was to assess the association between bicycle riding and weight control in premenopausal women. METHODS This was a 16-year follow-up study of 18,414 women in the Nurses' Health Study II. Weight change between 1989 and(More)
BACKGROUND Little is known about the association between eating patterns and type 2 diabetes (T2D) risk. OBJECTIVE The objective of this study was to prospectively examine associations between breakfast omission, eating frequency, snacking, and T2D risk in men. DESIGN Eating patterns were assessed in 1992 in a cohort of 29,206 US men in the Health(More)
The isotemporal substitution model (ISM) was previously developed as a methodology to study the time-substitution effects of 1 type of activity for another in a data setting with continuous outcomes. To demonstrate the application of ISM with a dichotomous outcome, we prospectively examined the associations of different activities with various activity(More)
The results of most case-control studies have suggested a positive association between eating frequency and colorectal cancer risk. Because no prospective cohort studies have done so to date, the authors prospectively examined this association. In 1992, eating frequency was assessed in a cohort of 34,968 US men in the Health Professionals Follow-up Study.(More)