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Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of… (More)
- Delu Zhou, Ping Li, +5 authors Janice S Blum
- Immunity
- 2005
Extracellular antigens are internalized and processed before binding MHC class II molecules within endosomal and lysosomal compartments of professional antigen presenting cells (APC) for subsequent… (More)
- Sebastian Joyce, Amina S Woods, +6 authors Randy R Brutkiewicz
- Science
- 1998
Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen-like molecules, controls the differentiation and function of a T lymphocyte subset, NK1+ natural T… (More)
- Andres G Grandea, Tatiana N. Golovina, +6 authors Luc Van Kaer
- Immunity
- 2000
Loading of peptides onto major histocompatibility complex class I molecules involves a multifactorial complex that includes tapasin (TPN), a membrane protein that tethers empty class I glycoproteins… (More)
- Venkataraman Sriram, Wenjun Du, Jacquelyn Gervay-Hague, Randy R Brutkiewicz
- European journal of immunology
- 2005
The current consensus on characterization of NKT cells is based on their reactivity to the synthetic glycolipid, alpha-galactosylceramide (alpha-GalCer) in a CD1d-dependent manner. Because of the… (More)
- Christopher C Norbury, Michael F. Princiotta, +5 authors Jonathan W. Yewdell
- Journal of immunology
- 2001
Current knowledge of the processing of viral Ags into MHC class I-associated ligands is based almost completely on in vitro studies using nonprofessional APCs (pAPCs). This is two steps removed from… (More)
- Gourapura J. Renukaradhya, Tonya J Roberts Webb, +4 authors Randy R Brutkiewicz
- Journal of immunology
- 2005
A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the… (More)
- Kristi L. Williams, Alfred J. Zullo, +4 authors Elizabeth J Taparowsky
- Journal of immunology
- 2003
The importance of regulated AP-1 activity during T cell development was assessed using transgenic mice overexpressing BATF, a basic leucine zipper transcription factor and an AP-1 inhibitor. BATF… (More)
- Randy R Brutkiewicz, Jack R. Bennink, Jonathan W. Yewdell, Albert Bendelac
- The Journal of experimental medicine
- 1995
CD1 molecules consist of beta 2-microglobulin (beta 2m) noncovalently complexed to a non-major histocompatibility complex (MHC)-encoded monomorphic integral membrane protein homologous to MHC class I… (More)
Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory functions and recognize CD1d molecules. The majority of NKT cells express an invariant T-cell receptor (TCR)… (More)