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  • Randy M Wadkins, Janice L. Hyatt, +9 authors Philip M Potter
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2005 (First Publication: 1 April 2005)
  • Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification ofContinue Reading
  • Randy M Wadkins, Christopher L. Morton, +4 authors Philip M Potter
  • Biology, Medicine
  • Molecular pharmacology
  • 2001 (First Publication: 1 August 2001)
  • 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin [CPT-11 (irinotecan)] is a water-soluble camptothecin-derived prodrug that is activated by esterases to yield the potentContinue Reading
  • Christopher L. Morton, Randy M Wadkins, Mary K. Danks, Philip M Potter
  • Medicine
  • Cancer research
  • 1999 (First Publication: 1 April 1999)
  • Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitroContinue Reading
  • Janice L. Hyatt, Vanessa Stacy, +8 authors Philip M Potter
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2005 (First Publication: 1 August 2005)
  • Benzil has been identified as a potent selective inhibitor of carboxylesterases (CEs). Essential components of the molecule required for inhibitory activity include the dione moiety and the benzeneContinue Reading