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BACKGROUND Most infants with congenital Toxoplasma gondii infection have no symptoms at birth, but many will have retinal disease or neurologic abnormalities later in life. Early detection and treatment of congenital toxoplasmosis may reduce these sequelae. METHODS In Massachusetts since January 1986, and in New Hampshire since July 1988, newborns have(More)
Culture forms of 104 stocks of Trypanosoma cruzi isolated in different regions of the State of Bahia were compared by electrophoresis of six enzymes. The three distinct combinations of isoenzyme patterns seen were designated ZI, Z2 and Z3. In an area of endemic Chagas's disease in eastern Bahia, T. cruzi Z1 was associated with sylvatic mammals and sylvatic(More)
The evolution of Chagas' cardiomyopathy is poorly understood. We therefore examined the development of cardiac lesions in a rural Brazilian community for a period of 7 years. Initially, 42% of 1017 residents were seropositive for infection with Trypanosoma cruzi. Age-specific infection rates indicated that most had become infected before the age of 20(More)
BACKGROUND In acute psychiatry the prescribed medication is frequently off-label. AIM To investigate the indications for off-label prescriptions described in the literature and to evaluate the use of off-label medication in the emergency service of Altrecht, Utrecht, The Netherlands. METHOD We performed a systematic search of the PubMed database and we(More)
We compare results of one Bell and one Kato-Katz examination performed on each of 315 stool specimens from residents in an area in north-eastern Brazil endemic for schistosomiasis mansoni. The prevalence of Schistosome infection detected by the Bell technique was 76% and by the Kato-Katz technique was 63%. 81% (44/54) of the infections missed by a Kato-Katz(More)
Attempts to predict the course of the epidemic of acquired immunodeficiency syndrome (AIDS) have been hampered by the lack of an objective, practical way to estimate the prevalence of infection with the human immunodeficiency virus (HIV) in the general population. Testing for the prevalence of HIV infection in women should be a sensitive means to track the(More)
This prospective study has shown that oxamniquine treatment controlled endemic schistosomiasis mansoni in a defined rural population in Castro Alves, north-east Brazil. Data before and after treatment spanning 11 years were collected for a cohort of 191 residents. Before treatment (1974-77), the cohort was heavily infected and the prevalence of associated(More)