Randy Appleton

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Despite impressive advances in file system throughput resulting from technologies such as high-bandwidth networks and disk arrays, file system latency has not improved and in many cases has become worse. Consequently, file system I/O remains one of the major bottlenecks to operating system performance [10]. This paper investigates an automated predictive(More)
Conventional le systems suuer from high access latencies Ous90]. To complicate matters, emerging technologies such as wireless computing, telecommuting environments, read/write CD-ROM systems, and wide area le systems often exhibit higher latencies than conventional le systems. This paper describes the design, implementation, and evaluation of a predictive(More)
File systems have become slow relative to processor , memory and network speeds. The high latencies of distributed le systems (particularly wide area le systems) have only exacerbated the problem. We believe that le system prefetching provides an eeective method for alleviating the latency bottleneck. File system prefetching requires knowledge of future le(More)
Previous results [ACM87] show that the timeout strategy of deadlock detection performs poorly in a single site database. But because of the restrictions imposed on heterogeneous multidatabases, the traditional alternatives are not possible. This paper proposes a new deadlock detection strategy within the restrictions of heterogeneous multidatabases, one(More)
When space-filling models of the peroxy radical precursor of PGG were compared with models of 2(S)-(3-chloro-4-cyclohexylphenyl)propionic acid and other acidic cyclooxygenase inhibitors several common structural features were revealed. This led us to propose a template for synthesising non-steroidal anti-inflammatory drugs (NSAIS's) based on the geometry of(More)
A series of substituted chromone-2-carboxylic acids was synthesized and tested as antagonists of SRS-A induced contractions of isolated guinea pig ileum. This work led to the discovery of sodium 7-[3-(4-acetyl-3hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate (FPL 55712) which is the first reported specific antagonist(More)
When space-filling models of the peroxy radical precursor of PGG were compared with models of 2(S)-(3-chloro-4-cyclohexylphenyl) propionic acid and other acidic cyclooxygenase inhibitors several common structural features were revealed. This led us to propose a template for designing non-steroidal anti-inflammatory drugs (NSAID's) based on the conformation(More)
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