Randolph L. Winter

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OBJECTIVE To determine the effect of PO administration of pimobendan on clinical and echocardiographic variables and survival time in cats with heart failure characterized by ventricular systolic dysfunction. DESIGN Retrospective cohort study. ANIMALS 27 client-owned cats (16 male and 11 female) with heart failure, treated with pimobendan (mean ± SD(More)
INTRODUCTION To determine the biologic variability of N-terminal pro-brain natriuretic peptide (NTproBNP) in healthy dogs and dogs with various stages of myxomatous mitral valve disease (MMVD). ANIMALS Thirty-eight privately owned dogs: 28 with MMVD and 10 healthy controls. MATERIALS AND METHODS Prospective clinical study with comprehensive evaluation(More)
A 6 yr old female spayed large Munsterlander was evaluated following a 3 wk history of lethargy, inappetence, intermittent fever, and a recent change to the timing of her previously diagnosed heart murmur. Physical examination revealed marked dehydration, lethargy, and a grade 5/6 to-and-fro heart murmur that was auscultated best at the right sternal(More)
OBJECTIVES To describe characteristics of echocardiography and cranial coelomic radiography in a cohort of iguanas. ANIMALS Twenty apparently healthy adult green iguanas (Iguana iguana) from a reptile sanctuary. METHODS Physical examination, radiography, two-dimensional and color Doppler echocardiography were performed to assess cardiac structures and(More)
BACKGROUND Biologic variability (BV) is one aspect of interpreting changes in biomarker concentrations known to be clinically important in people with cardiac disease, but it has not been adequately addressed in dogs so far. OBJECTIVES The purpose of the study was to determine BV of cardiac troponin I (cTnI) in healthy dogs and dogs with 3 stages of(More)
INTRODUCTION Notched QRS complexes on electrocardiography (ECG) have been described in veterinary and human reports, but little is known about this finding in veterinary patients. Therefore, the objectives of this study were to describe the signalment and cardiac disease diagnosis in dogs with notched QRS complexes, as well as to describe the specific leads(More)
A common challenge in cell therapy is the inability to routinely maintain survival and localization of injected therapeutic cells. Delivering cells by direct injection increases the flexibility of clinical applications, but may cause low cell viability and retention rates due to the high shear forces in the needle and mechanical wash out. In this study, we(More)
OBJECTIVES The pathogenesis and presentation of aortic thrombosis (AT) in dogs is not well characterized and an effective antithrombotic therapy for AT in dogs has not been identified. Our goal is to report the clinical presentation and results of therapies in dogs with AT. ANIMALS Twenty-six client-owned dogs. METHODS Retrospective review of medical(More)
A 3-day-old Hereford heifer calf presented for evaluation of lethargy and dyspnea, with persistent hypoxia despite supplemental oxygen therapy. A grade III/VI right apical systolic murmur was noted during cardiac auscultation. Echocardiography revealed a double-outlet right ventricle with an intact interventricular septum and concurrent hypoplastic left(More)
OBJECTIVE To assess signalment and concurrent disease processes in dogs with aortic thrombotic disease (ATD). DESIGN Retrospective case-control study. ANIMALS Dogs examined at North American veterinary teaching hospitals from 1985 through 2011 with medical records submitted to the Veterinary Medical Database. PROCEDURES Medical records were reviewed to(More)