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FOXO3A genotype is strongly associated with human longevity
Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1Expand
Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study
BACKGROUND A generally held belief is that cholesterol concentrations should be kept low to lessen the risk of cardiovascular disease. However, studies of the relation between serum cholesterol andExpand
Performance‐Based Measures of Physical Function for High‐Function Populations
OBJECTIVES: To improve and broaden the applicability of performance‐based measures of function for use in clinical and research settings.
Plasma Fibrinogen as a Predictor of Total and Cause-Specific Mortality in Elderly Japanese-American Men
Abstract—The relation between plasma fibrinogen and total and cause-specific mortality was investigated in a cohort of 3571 Japanese-American men aged 71 to 93 years during a median follow-up of 4.4Expand
Midlife risk factors and healthy survival in men.
CONTEXT Healthy survival has no clear phenotypic definition, and little is known about its attributes, particularly in men. OBJECTIVE To test whether midlife biological, lifestyle, andExpand
Are depressive symptoms a risk factor for mortality in elderly Japanese American men?: the Honolulu-Asia Aging Study.
OBJECTIVE This study determined the influence of depressive symptoms on subsequent mortality of all causes. METHOD The Honolulu Heart Program, established in 1965, is a prospective, community-basedExpand
The Relationship of Psychosocial Factors to Total Mortality Among Older Japanese‐American Men: The Honolulu Heart Program
OBJECTIVE: To examine the predictive value of psychosocial factors as risk factors for all‐cause mortality.
High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program.
High density lipoprotein (HDL) cholesterol has been inversely associated with coronary heart disease. Associations with stroke are less clear, particularly among the elderly. In this study, theExpand
Burden of infection in patients with end-stage renal disease requiring long-term dialysis.
BACKGROUND This study examines the spectrum of infections in a selected population of patients requiring long-term dialysis, enlarging the focus beyond infections associated with the dialysisExpand
Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry
Objectives To determine the relation between height, FOXO3 genotype and age of death in humans. Methods Observational study of 8,003 American men of Japanese ancestry from the Honolulu HeartExpand