Randall Whitcomb

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Measurement of the urinary excretion of lutropin (LH) and follitropin (FSH) and their common free alpha subunit (FAS) assists in monitoring the maturation of the hypothalamic-pituitary-gonadal axis and in understanding the physiology of the pituitary glycoprotein hormones. Here we describe sensitive, specific polyclonal radioimmunoassays for LH and FSH and(More)
  • Parke-Davis Pharmaceutical Research, Ann A R B O R, +4 authors Randall Whitcomb
  • 2000
T he pro g ression of diabetes involves multiple stages from impaired glucose tolerance (IGT) to advanced diabetes (1). The standard treatment of type 2 diabetes , there f o re, pro g resses with the disease f rom diet and exercise only, to oral antidia-betic medications, to combination therapy of d i ff e rent classes of antidiabetic agents, and eventually(More)
GnRH pulse frequency, amplitude, and interpulse interval have all been demonstrated to regulate gonadotropin secretion individually. We tested the hypothesis that the contour of the GnRH pulse also modulates gonadotropin output in 10 men with isolated GnRH deficiency in whom a fixed GnRH dose was administered at a constant physiologic frequency by either(More)
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