A previously proposed model for memory based on neurophysiological considerations is reviewed. We assume that (a) nervous system activity is usefully represented as the set of simultaneous individual neuron activities in a group of neurons; (b) different memory traces make use of the same synapses; and (c) synapses associate two patterns of neural activity… (More)
Proton magnetic resonance spectroscopy (1H-MRS) allows major metabolites to be measured noninvasively in defined regions of the living brain, and can detect biochemical abnormalities where conventional structural imaging appears normal. MRS can be performed in 10 min as part of a clinical MRI examination. Biochemical abnormalities in Alzheimer's Disease… (More)
We describe the case of a patient with Wilson's disease who was first seen with distractibility of gaze fixation. Clinical and magnetic resonance imaging studies suggest that the disorder was probably due to frontal lobe involvement.