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BACKGROUND This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein apical membrane antigen-1 (AMA-1) representing the 3D7 allele formulated with either the AS01B or AS02A Adjuvant Systems. METHODOLOGY/PRINCIPAL FINDINGS After a preliminary safety(More)
In experiments with adult rabbits the active microvascular segments located at particular sites of the minor pial arterial ramifications were investigated. These appeared as sphincters at off-shoots of the arterial branches, the precortical arteries, and the arterial microanastomoses. The sphincters and the precortical arteries were found plentifully(More)
At var ious s tages of embryonic and postnatal development the dis t r ibut ion of ad renerg ie f ibe rs and the ca techolamine content were invest igated in the h e a r t r e l a t i v e l y ma tu re (guinea pig) and immatu re (rat, rabbit) at bir th. Cateeholamines were es t imated by the method of Eu le r and Floding, and adrenerg ie f ibe r s demons t(More)
The influence of sympathectomy of the ear artery in rabbits on the activity of a number of redox coenzymes inthe vascular wall (lactic, glucose-6-phosphoric, isocitrate, and succinic dehydrogenases: LDH, G-6-PDHm isoCDH, and SDH, respectively) was studied by the quantitative histochemical method. Sympathectomy produced a significant diminution of all the(More)
Histochemical and electron microscopic investigation on dynamics of ultrastructure and adrenergic innervation formation in the wall of the femoral artery and vein, in the mesenteric artery and vein and in the aorta has been performed in 10-20-day-old chick embryos and in chickens during first days of life. In the course of embryogenesis, myoblasts of the(More)
The adrenergic innervation of blood vessel wall was studied in various vascular beds of adult rats with experimental hypertension induced by the constriction of the aorta between the origins of both renal arteries. A moderate expansion of body fluids was demonstrated in this hypertensive model. The decrease of the density of adrenergic plexus in the vessel(More)
Using histochemical fluorescence technique, studies have been made on the adrenergic innervation of the wall of the thoracal lymphatic duct in postnatal development of puppies. Adrenergic fibers were found in the adventitial layer of the duct. During postnatal development of the animals, adrenergic innervation of this duct becomes more perfect, reaching the(More)