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Europeans and Americans have often "talked past" each other about aspects of organizational life. One such aspect is user involvement in systems development. The methodologies of Participatory Design (PD) and Joint Application Design (JAD) have established themselves in Scandinavia and North America as. influential thrusts in software development, yet there(More)
Expert Systems (ES) are as yet imperfectly defined. Their two consistently cited characteristics are domain knowledge and expert-level performance. We propose that current structural definitions are inadequate and suggest a view of ES as communication channels. We proceed to explore the factors influencing applicability of ES technology to an enterprise and(More)
Here, we investigate the highly specific interaction of the BamHI endonuclease with its cognate recognition sequence GGATCC by determining which amino acid residues can be substituted at the DNA interface while maintaining specificity. Mutational studies, together with the structural determination of the restriction endonuclease BamHI have revealed the(More)
Amino acid residues Asn116 and Ser118 of the restriction endonuclease BamHI make several sequence-specific and water-bridged contacts to the DNA bases. An in vivo selection was used to isolate BamHI variants at position 116, 118 and 122 which maintained sequence specificity to GGATCC sites. Here, the variants N116H, N116H/S118G and S118G were purified and(More)
The work-centered support system approach to human-centered computing focuses on analyzing and supporting the multiple facets of work. The WCSS for global weather management developed to support weather forecasting and monitoring in an airlift service organization, exemplifies this approach. A hallmark of human-centered computing (HCC) is its focus on(More)
munities are interested in understanding cyberspace as a business venue. To date, understanding has been pursued by analysing the cyber-space venue using presumptions from theories and practices evolved in and for the traditional business venue of the physical world ('real space'). We believe the results have been poor, because these communities(More)
In this paper we provide an overview of our research investigating what functionality should be provided to users of a future Joint Battlespace Infosphere (JBI). We characterize and discuss the development of the JBI as a new form of automation that employs intelligent agents to autonomously seek, retrieve, and fuse information We believe that the(More)
munities are interested in understanding cyberspace as a business venue. To date, understanding has been pursued by analysing the cyber-space venue using presumptions from theories and practices evolved in and for the traditional business venue of the physical world ('real space'). We believe the results have been poor, because these communities(More)
Commanders' Predictive Environment (CPE) is a multi-year program that has been undertaken by the Air Force Research Laboratory to develop ways to allow commanders to better anticipate and predict the outcomes of actions of both allied and opponent forces. One objective of this program is to use intuitive and innovative visualization techniques to present(More)
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