• Publications
  • Influence

Claim Your Author Page
Ensure your research is discoverable on Semantic Scholar. Claiming your author page allows you to personalize the information displayed and manage your publications. Semantic Scholar automatically creates author pages based on data aggregated from public sources and our publisher partners.
  • Rana S. Moubarak, Victor J Yuste, +4 authors Santos A Susin
  • Medicine, Biology
  • Molecular and cellular biology
  • 2007 (First Publication: 1 July 2007)
  • Alkylating DNA damage induces a necrotic type of programmed cell death through the poly(ADP-ribose) polymerases (PARP) and apoptosis-inducing factor (AIF). Following PARP activation, AIF is releasedContinue Reading
  • Miguel F. Segura, Carme Solé, +11 authors Joan X. Comella
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2007 (First Publication: 17 October 2007)
  • Death receptors (DRs) and their ligands are expressed in developing nervous system. However, neurons are generally resistant to death induction through DRs and rather their activation promotesContinue Reading
  • Cécile Delettre, Victor J Yuste, Rana S. Moubarak, Marlène Bras, Nadine Robert, Santos A Susin
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2006 (First Publication: 7 July 2006)
  • Apoptosis-inducing factor (AIF) is a bifunctional NADH oxidase involved in mitochondrial respiration and caspase-independent apoptosis. Three alternatively spliced mRNA isoforms of AIF have beenContinue Reading
  • Cécile Delettre, Victor J Yuste, +5 authors Santos A Susin
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2006 (First Publication: 10 March 2006)
  • AIF is a main mediator of caspase-independent cell death. It is encoded by a single gene located on chromosome X, region q25–26 and A6 in humans and mice, respectively. Previous studies establishedContinue Reading
  • Paulina Carriba, Sebastián Jiménez, +7 authors Joan X. Comella
  • Biology, Medicine
  • Cell Death and Disease
  • 2015 (First Publication: 1 February 2015)
  • The brains of patients with Alzheimer’s disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine that has a dual function in neuronal cells. On one hand, TNFα can activateContinue Reading
  • Victor J Yuste, Isabel Sánchez-López, +6 authors Joan X. Comella
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2005 (First Publication: 21 October 2005)
  • We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the nuclear morphology and DNA degradation pattern in staurosporine-inducedContinue Reading