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Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans
  • Tao He, Ran Wang, +25 authors Yang Wang
  • Biology, Medicine
  • Nature Microbiology
  • 27 May 2019
The findings suggest that both the surveillance of tet(X) variants in clinical and animal sectors and the use of tetracyclines in food production require urgent global attention. Expand
Bio-Control of Salmonella Enteritidis in Foods Using Bacteriophages
Two lytic phages isolated from chicken sewage and characterized with host strains Salmonella Enteritidis and ATCC13076 and CVCC2184 belonged to the family Myoviridae, and showed potential effectiveness as a bio-control agent ofSalmonella in foods. Expand
Staphylococcus aureus Bacteriophage Suppresses LPS-Induced Inflammation in MAC-T Bovine Mammary Epithelial Cells
The ability of vB_SauM_JS25 to influence the immune response highlights the potential development and application of bacteriophage-based therapies and may represent a novel anti-inflammatory therapeutic strategy. Expand
Isolation and lytic activity of the Listeria bacteriophage endolysin LysZ5 against Listeria monocytogenes in soya milk.
The endolysin gene (lysZ5) from the genome of the Listeria monocytogenes phage FWLLm3 was cloned in Escherichia coli and characterized and was able to control pathogens in soya milk and to demonstrateendolysin activity in foods at refrigeration temperatures. Expand
Population structure and antimicrobial profile of Staphylococcus aureus strains associated with bovine mastitis in China.
The results of this study illustrated the distribution, antimicrobial susceptibility profiles, genotype, and the ability of biofilm production and mammary epithelial cells invasion of these S. aureus isolates that can provide the basis for the development of a disease prevention program in dairy farms to reduce the potential risk in both animal and human health. Expand
Molecular and virulence characterization of highly prevalent Streptococcus agalactiae circulated in bovine dairy herds
This study provides substantial evidence for the hypothesis that the virulence characteristics including efficient growth in milk, elevated biofilm formation ability, together with strong adhesion ability might have favored the high prevalence of the STs in the bovine environment, whereas the hemolytic activity and cytotoxicity were not the crucial characteristics. Expand
Characterization of NDM-5-positive extensively resistant Escherichia coli isolates from dairy cows.
  • Tao He, Ruicheng Wei, +4 authors Yang Wang
  • Biology, Medicine
  • Veterinary microbiology
  • 1 August 2017
Plasmid stability testing showed that both blaNDM-5 and mcr-1-carrying plasmid maintained stable in the hosts after ten passages without antimicrobial selection, suggesting that active surveillance efforts are imperative to monitor the prevalence of bla NDM- 5 and mCR-1 in carbapenem-resistant Enterobacteriaceae from dairy farms throughout China. Expand
The lytic activity of recombinant phage lysin LysKΔamidase against staphylococcal strains associated with bovine and human infections in the Jiangsu province of China.
The present results suggest that LysKΔamidase has the potential to be an alternative therapeutic agent against pathogenic methicillin-resistant and-susceptible staphylococcal strains isolated from China. Expand
Occurrence and characterization of blaNDM-5-positive Klebsiella pneumoniae isolates from dairy cows in Jiangsu, China
The IncX3 pNDM-MGR194-like plasmid disseminated among cow farms should be highlighted and its potential role in mediating transmission of the blaNDM gene between bacteria from humans and animals requires further monitoring. Expand
Insights Into the Bovine Milk Microbiota in Dairy Farms With Different Incidence Rates of Subclinical Mastitis
Overall, this study showed complex diversity between the milk microbiota in dairy farms with different IRSCM, which suggests that variation in IRSCMs may not only be determined by the heterogeneity and prevalence of mastitis-causing pathogens but also be associated with potential beneficial bacteria. Expand