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A convenient and highly efficient multicomponent protocol has been developed for the synthesis of various poly-substituted 2-(pyridin-2-yl)imidazoles from 2-cyanopyridine, corresponding aromatic aldehydes, and NH(4)OAc/primary amine. Notably, tri-substituted 2-(pyridin-2-yl)imidazoles were highly yielded when aromatic primary amines were used as substrates,(More)
PURPOSE To investigate changes in the optic nerve head morphology after acute intraocular pressure (IOP) elevation during a dark room prone provocative test (DRPPT). DESIGN Prospective cohort study. PARTICIPANTS Acute primary angle-closure (APAC) suspects underwent DRPPT. METHODS Study participants stayed in a dark room for 2 hours with the forehead(More)
The tumor suppressor gene TP53 and its negative regulator murine double minute 2 are involved in multiple cellular pathways. Two potentially functional single nucleotide polymorphisms (SNPs) MDM2 SNP309 and TP53 R72P have been extensively investigated to be associated with breast cancer risk. However, the original studies as well as the subsequent(More)
PURPOSE To assess changes in the peripapillary retinal pigment epithelium (RPE) in association with an acute intraocular pressure (IOP) elevation provoked by a dark room prone provocative test (DRPPT). DESIGN Prospective, comparative clinical observational study. PARTICIPANTS Nineteen study group eyes (14 individuals) and 26 control eyes (21 patients).(More)
Alkaline coal fly ash and lime were tested for their effectiveness in pathogen removal from biosolids at different time intervals and temperatures. Coal fly ash at 10 and 35% w/w was mixed with dewatered biosolids and then the ash-biosolids mixture was mixed separately with 0, 1.1, 2.2, 4.4, 8.5, 11, and 18% calcium oxide (w/w on a dry weight basis) with(More)
PURPOSE To measure peripapillary choroidal thickness (PPCT) and to assess its associations. METHODS The population-based cross-sectional Beijing Eye Study 2011 included 3468 participants. Detailed medical and ophthalmic examinations were performed. We measured PPCT by spectral-domain optical coherence tomography (SD-OCT) with a 3.4-mm scan circle centered(More)
Organocatalyzed asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media has been developed. The reactions proceeded efficiently in the presence of the MacMillan catalyst to give the desired products in good to excellent yields with moderate diastereoselectivities and excellent enantioselectivities.
PURPOSE To evaluate changes in subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (PPCT) after acute intraocular pressure (IOP) elevation provoked by a dark room prone provocative test (DRPPT). METHODS The prospective cohort study included 114 eyes from 65 individuals who had an IOP elevation ≥2 mm Hg during the DRPPT. The(More)
Web access mode is the most popular and effective way to share resources between universities nowadays. Considering the opening and complexity of the Internet, Secure and authorized access resources method becomes a key problem. This paper proposed an access control mechanism based on RBAC (Role Based Access Control) for information and telecommunication(More)