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BACKGROUND Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane(More)
BACKGROUND Roughly, 10% of elderly patients develop postoperative cognitive dysfunction. General anesthesia impairs spatial memory in aged rats, but the mechanism is not known. Hippocampal neurogenesis affects spatial learning and memory in rats, and isoflurane affects neurogenesis in neonatal and young adult rats. We tested the hypothesis that isoflurane(More)
BACKGROUND Millions of neonates undergo anesthesia each year. Certain anesthetic agents cause brain cell death and long-term neurocognitive dysfunction in postnatal day (P)7 rats. Despite its intuitive appeal, a causal link between cell death and neurocognitive decline after anesthesia has not been established. If one existed, the degree of cell death would(More)
— In this paper, we examine optimization-based methods for designing the network topology when the desired topology should have certain global variational properties , such as minimal power consumption for information exchange links, or supporting fast convergence of consensus-based distributed protocols. We first classify the optimization-based methodology(More)
— In this paper the problem of optimal path planning and power allocation for an Unmanned Aerial Vehicle (UAV) is explored. The UAV is equipped with photovoltaic cells on top of its wings and its energy sources are solar power and rechargeable batteries. The Sun incidence angle on the photovoltaic cells, which subsequently affects energy harvesting, is(More)
Biotin biosynthesis is essential for survival and persistence of Mycobacterium tuberculosis (Mtb) in vivo. The aminotransferase BioA, which catalyzes the antepenultimate step in the biotin pathway, has been established as a promising target due to its vulnerability to chemical inhibition. We performed high-throughput screening (HTS) employing a fluorescence(More)