Ramya Sundararajan

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It is widely appreciated that neurotransmission systems interact in their effects on human cognition, but those interactions have been little studied. We used genetics to investigate pharmacological evidence of synergisms in nicotinic/muscarinic interactions on cognition. We hypothesized that joint influences of nicotinic and muscarinic systems would be(More)
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitochondrial DNA (mtDNA) damage can compromise mitochondrial function, we examined whether LRRK2 mutations can(More)
Efficient in vitro differentiation into specific cell types is more important than ever after the breakthrough in nuclear reprogramming of somatic cells and its potential for disease modeling and drug screening. Key success factors for neuronal differentiation are the yield of desired neuronal marker expression, reproducibility, length, and cost. Three main(More)
We investigated the relation between the two systems of visuospatial attention and working memory by examining the effect of normal variation in cholinergic and noradrenergic genes on working memory performance under attentional manipulation. We previously reported that working memory for location was impaired following large location precues, indicating(More)
We hypothesized that normal variation in genes influencing the bioavailability of dopamine in prefrontal cortex contribute to inter-individual differences in working memory (WM), particularly in healthy old age. To test this, 858 healthy young, middle-aged, and older people were tested on a spatial WM task and genotyped for catechol-O-methyltransferase(More)
  • K Ranganathan, R Arulkumaran, D Kamalakkannan, R Sundararajan, S P Sakthinathan, S Vijayakumar +5 others
  • 2006
A series of substituted styryl 5-chloro-2-thienyl ketones have been synthesized by microwave assisted Silica-H 2 SO 4 catalyzed green Crossed-Aldol condensation of 2-acetyl-5-chlorothiophene and substituted benzaldehydes. These chalcones were characterized by their physical constants and spectral data. From IR and NMR spectra, the spectral frequencies of(More)
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