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The interaction of proteins with surfaces is important in separation and purification procedures as well as in metabolism and its regulation. The degree of binding to a given surface in principle depends on the precise amino acid composition of the protein, although very little is presently known about the relationship between amino acid sequence and(More)
Modeling the kinetics of protein adsorption at solid surfaces is needed to predict protein separations, design biosensors, and determine the body's initial response to foreign objects. We develop, at the particle level, a kinetic model that accounts geometrically for the surface blockage due to adsorption and postadsorption conformational (or orientational)(More)
INTRODUCTION: The family of fibroblast growth factor (FGF) and their receptors (FGFRs) play a critical role in nervous system development. Aberrant expression or a change in the pattern of their expression may contribute to neural tumour formation. The FGFR expression status in vestibular schwannoma is unknown. AIM: To characterize the pattern of FGFR-1,(More)
Aims of Study The invasive nature of conventional cystometry has encouraged the development of alternative urodynamic techniques that do not require bladder catheterisation. Most noninvasive methods rely on flow interuption during voiding to allow an estimate of isovolumetric bladder pressure. The currently available methods include mechanical interuption(More)
INTRODUCTION: Goitrogenesis is thought to be due to hyperstimulation of the thyroid stimulating hormone (TSH) receptor and is associated with dramatic andiogenesis within the thyroid. The angiogenic growth factors, fibroblast growth factor (FGF-2) and its receptor (FGFR-1) as well as Tie-2 (the receptor for the angiopoietins) are elevated in both the human(More)
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