Ramona van Heerebeek

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INTRODUCTION Genetic and disease-related factors give rise to a wide spectrum of glucocorticoid (GC) sensitivity in rheumatoid arthritis (RA). In clinical practice, GC treatment is not adapted to these differences in GC sensitivity. In vitro assessment of GC sensitivity before the start of therapy could allow more individualized GC therapy. The aim of the(More)
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of metabolism, changes in TH signaling have widespread effects. Here, we reveal a significant common(More)
Context The pathogenesis of tyrosine kinase inhibitor-induced thyroid hormone (TH) alterations and the effects on TH metabolism and transport are still a matter of debate. Objective To study the effects of sorafenib on TH levels in patients with hepatocellular carcinoma (HCC) and evaluate possible mechanisms underlying these changes. Design Prospective(More)
OBJECTIVE Glucocorticoid (GC) sensitivity is highly variable among individuals and has been associated with susceptibility to develop (auto-)inflammatory disorders. The purpose of the study was to assess GC sensitivity in Behçet's disease (BD) by studying the distribution of four GC receptor (GR) gene polymorphisms and by measuring in vitro cellular GC(More)
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