Ramona R Swaby

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The ubiquitous application of selective oestrogen receptor modulators (SERMs) and aromatase inhibitors for the treatment and prevention of breast cancer has created a significant advance in patient care. However, the consequence of prolonged treatment with antihormonal therapy is the development of drug resistance. Nevertheless, the systematic description(More)
L-Buthionine sulfoximine (BSO) is a potent inhibitor of glutathione biosynthesis and studies have shown that it is capable of enhancing the apoptotic effects of several chemotherapeutic agents. Previous studies have shown that long-term antihormonal therapy leads to acquired drug resistance and that estrogen, which is normally a survival signal, is a potent(More)
Synthetic oestrogens based either on the structure of triphenylethylene or the very potent but shorter acting diethylstilboestrol [5,6] were described more than 60 years ago. This proved to be a cheap source of new medicines. High-dose synthetic oestrogen administration was found to be effective in the treatment of breast and prostate cancer [7], but(More)
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