Ramona Guarino

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This review is intended to discuss recent developments in the molecular pharmacology of the alpha 1-adrenergic receptor (alpha 1-AR) subtypes. After a brief historical development, we will focus on the more contemporary issues having to do with this receptor family. Emphasis will be put on recent data regarding the cloning, nomenclature, signalling(More)
With a selective antagonist, the specific contribution of the alpha-1D adrenoceptor (AR) to vascular smooth muscle contraction has been assessed. BMY 7378 bound to membranes expressing the cloned rat alpha-1D AR with a > 100-fold higher affinity (K1 = 2 nM) than binding to either the cloned rat alpha-1A AR (Ki = 800 nM) or the hamster alpha-1B AR (Ki = 600(More)
In the present study, we showed that, in a social gambling task, individuals are influenced more by the type of social interaction than by the pattern of gains and losses. More precisely, the neural responses, as well as the level of pleasantness/unpleasantness following gains and losses, are modulated by social interaction factors. Here we present an(More)
The contribution of the alpha-1B adrenergic receptor (AR) to vascular smooth muscle contraction has been assessed using a combination of immunological, molecular biological and pharmacological approaches. A subtype-selective antibody detected alpha-1B immunoreactivity in the medial layer of the aorta, caudal, femoral, iliac, mesenteric resistance, renal and(More)
BACKGROUND Cognitive reserve could be defined as the accumulation of experiences, abilities, knowledge and changes that occur throughout the lifespan. One of the most difficult changes in life is the experience of emigrating to a foreign country. AIMS The present investigation aimed to compare the cognitive reserve of two paired groups of elderly:(More)
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