Ramona Granda

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The chick brain is a useful model system for studying the ontogeny and phylogeny of neural circuitry, especially that of the visual system. In this study the distribution of cells and processes showing GABA-like immunoreactivity (GABA+) in the diencephalon and mesencephalon of the posthatch chick was determined immunohistochemically with a polyclonal(More)
We test the interlinked hypotheses that in healthy older adults: 1). i.v. injection of GH-releasing peptide-2 (GHRP-2) and GHRH synergizes more in aging women than men; 2). sc infusion of both GHRP-2 (1 microg/kg.h = 1) and GHRH (1, 3, or 10) for 24 h augments GH secretion more than either agonist alone; and 3). continuous sc delivery of GHRP-2 (1) for 30 d(More)
The retinogeniculate projection in the chick undergoes apparent augmentation following lesions in the optic tectum. Using autoradiographic tracing techniques we determined that the alteration of the retinal projection required a minimum of 4 days to be detected if tectal lesions were made at hatching and could be produced by lesions placed up to 1.5 years(More)
A population of cells has been found in the chick optic tract and chiasm exhibiting GABA-like immunoreactivity (GABA+; Granda and Crossland, J. Comp. Neurol. 287:455-469, '89). It is not known, however, whether the cells are neurons. We have studied the GABA+ cells by using morphological and immunocytochemical methods. We found that there are more than 500(More)
Immunohistochemical studies of the chicken embryo optic tract using an antibody to gamma-aminobutyric acid (GABA) reveal that the tract is initially free of GABA immunoreactive axons. During the second week of incubation, GABA+ axons appear in the tract, chiasm, and optic nerve. The number of GABA+ axons in the optic nerve increases through E18, although(More)
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