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The proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion. Intracellular reactive oxygen species and lipid peroxides rose rapidly in control cells depleted of glutathione, whereas cells expressing Bcl-2 displayed a blunted increase and(More)
We prove global wellposedness in the energy space of the defocusing cubic nonlinear Schrödinger and Gross-Pitaevskii equations on the exterior of a non-trapping domain in dimension 3. The main ingredient is a Strichartz estimate obtained combining a semi-classical Strichartz estimate [4] with a smoothing effect on exterior domains [10].
Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis of neural cells induced by glutathione(More)
Ginkgo biloba extract is known to be efficient in diseases associated with free radical generation. The purpose of this work was to study, under in vitro conditions, the action ofGinkgo biloba extract (Gbe) against superoxide anion ( $$O_{2^{\bar .} }$$ ), which is directly or indirectly implicated in cell damage. Gbe appears to have both an $$O_{2^{\bar .}(More)
Expression of the rate-limiting enzyme for catecholamine biosynthesis, tyrosine hydroxylase (TH), via retroviral and plasmid expression vectors improved the efficacy of conditionally immortalized nigral neural cells in ameliorating rodent and nonhuman primate models of Parkinson's disease through neural transplantation. No improvement in rotational behavior(More)
Long-term survival of grafted neural cells is a major goal of neural transplantation, but typical survival rates of grafted fetal neurons are in the range of 5-10%. Whether the death of transplanted neural cells is apoptotic or necrotic is unknown. The expression of the proto-oncogene bcl-2 inhibits both apoptotic and necrotic neural cell death. In a 6-OHDA(More)
Les Alliaceae constituent une famille botanique dont les constituants soufrés encore dénommés « glucosinolates » sont très originaux sur le plan chimique. Quelques généralités montreront les nombreuses structures qui sont libérées grâce aux réactions enzymatiques lors du broyage et de la mise en contact des contenus cellulaires. Quelques spécificités(More)