Ramin Karimi

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BACKGROUND The purpose of this study was to determine whether the therapeutic efficacy of fenretinide (4-HPR), a ceramide-generating anticancer agent, could be enhanced in prostate cancer cells by inclusion of a novel synthetic acid ceramidase (AC) inhibitor, DM102, a pivaloylamide of a 2-substituted aminoethanol. In prostate cancer, AC plays a role in(More)
Due to recent use of short-chain ceramides in preclinical studies, we characterized C6-ceramide metabolism in cancer cell lines and assessed metabolic junctures for enhancing efficacy. MDA-MB-231 breast cancer cells decreased the amount of C6-ceramide metabolized to C6-sphingomyelin (C6-SM) and increased the amount metabolized to C6-glucosylceramide (C6-GC)(More)
Poor prognosis in patients with later stage colorectal cancer (CRC) necessitates the search for new treatment strategies. Ceramide, because of its role in orchestrating death cascades in cancer cells, is a versatile alternative. Ceramide can be generated by exposure to chemotherapy or ionizing radiation, or it can be administered in the form of short-chain(More)
Vehicular Ad Hoc Networks are highly mobile wireless ad hoc networks. Routing of data in VANETs is a challenging task due to rapidly changing topology and high speed mobility of vehicles. Geographic routing protocols are becoming popular due to advancement and availability of GPS devices. In this paper, we review the existing non DTN Geographic Routing(More)
Delay Tolerant Networks (DTNs) are a class of networks that enable communication where connectivity issues like sparse connectivity, intermittent connectivity, high latency, long delay, high error rates, asymmetric data rate, and even no end-to-end connectivity exist. The DTN architecture model has been applied for vehicular Networks called Vehicular Delay(More)
P-glycoprotein (P-gp) antagonists inhibit ceramide metabolism at the juncture of glycosylation. The purpose of this study was to test whether targeting P-gp would be a viable alternative to targeting glucosylceramide synthase (GCS) for enhancing ceramide cytotoxicity. A2780 wild-type, and multidrug-resistant 2780AD and NCI/ADR-RES human ovarian cancer cell(More)
In the years, routing protocols in wireless sensor networks (WSN) have been substantially investigated by researches Most state-of-the-art surveys have focused on reviewing of wireless sensor network .In this paper we review the existing secure geographic routing protocols for wireless sensor network (WSN) and also provide a qualitative comparison of them.
Comprehensive effort for low-cost sequencing in the past few years has led to the growth of complete genome databases. In parallel with this effort, a strong need, fast and cost-effective methods and applications have been developed to accelerate sequence analysis. Identification is the very first step of this task. Due to the difficulties, high costs, and(More)
Vehicular communications have been considered to be an enabler for numerous vehicle safety and information applications. Many automobile manufacturers are indifferent stages of integrating communication devices in their vehicles for the purposes of safety, assisted drivers and entertainments. Because of the dynamic nature of mobile nodes in the network,(More)
New advances in rapid sequencing of large amounts of DNA have brought a great potential for the study of complex communities of microorganisms. One of the challenging problems is rapid identification of species from sequenced reads. Delays in the identification of pathogens are a barrier to the early diagnosis and proper treatment of infectious diseases. In(More)