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Calcific aortic valve (AV) disease has a high prevalence in the United States, and hypertension is correlated to early onset of the disease. The cause of the disease is poorly understood, although biological and remodeling responses to mechanical forces, such as membrane tension, have been hypothesized to play a role. The mechanical behavior of the native(More)
While aortic valve root compliance and leaflet coaptation have significant influence on valve closure, their implications have not yet been fully evaluated. The present study developed a full fluid–structure interaction (FSI) model that is able to cope with arbitrary coaptation between the leaflets of the aortic valve during the closing phase. Two(More)
A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97 % of BAVs include asymmetric cusps, little or no prior studies have investigated the blood flow through a three-dimensional BAV and root. The aim of the present study was to(More)
Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid–structure interaction (FSI) models. While cusp calcifications(More)
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