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Calcific aortic valve (AV) disease has a high prevalence in the United States, and hypertension is correlated to early onset of the disease. The cause of the disease is poorly understood, although biological and remodeling responses to mechanical forces, such as membrane tension, have been hypothesized to play a role. The mechanical behavior of the native(More)
While aortic valve root compliance and leaflet coaptation have significant influence on valve closure, their implications have not yet been fully evaluated. The present study developed a full fluid–structure interaction (FSI) model that is able to cope with arbitrary coaptation between the leaflets of the aortic valve during the closing phase. Two(More)
Native aortic valve cusps are composed of collagen fibers embedded in their layers. Each valve cusp has its own distinctive fiber alignment with varying orientations and sizes of its fiber bundles. However, prior mechanical behavior models have not been able to account for the valve-specific collagen fiber networks (CFN) or for their differences between the(More)
The complex three-dimensional (3D) geometry of the native tricuspid aortic valve (AV) is represented by select parametric curves allowing for a general construction and representation of the 3D-AV structure including the cusps, commissures and sinuses. The proposed general mathematical description is performed by using three independent parametric curves,(More)
A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97 % of BAVs include asymmetric cusps, little or no prior studies have investigated the blood flow through a three-dimensional BAV and root. The aim of the present study was to(More)
This study presents a combined computational and experimental approach for the nonlinear structural simulations of polymeric tri-leaflet aortic valves (PAVs). Nonlinear shell-based and quasi-static finite-element (FE) structural models are generated for a prosthetic valve geometry that includes the leaflets, stents and root materials, such as the bottom(More)
Calcific aortic valve disease (CAVD) is a progressive pathology characterized by calcification mainly within the cusps of the aortic valve (AV). As CAVD advances, the blood flow and associated hemodynamics are severely altered, thus influencing the mechanical performance of the AV. This study proposes a new method, termed reverse calcification technique(More)
A novel collagen-based bio-composite was constructed from micro-crimped long collagen fiber bundles extracted from a soft coral embedded in alginate hydrogel matrix. The mechanical features of this bio-composite were studied for different fiber fractions and in longitudinal and transverse loading modes. The tensile modulus of the alginate hydrogel was(More)
Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid–structure interaction (FSI) models. While cusp calcifications(More)
OBJECTIVE The aim of the present study was to determine the influence of the aortic annulus (AA) diameter in order to examine the performance metrics, such as maximum principal stress, strain energy density, coaptation area, and effective height in the aortic valve. METHODS Six cases of aortic roots with an AA diameter of 20 and 30 mm were numerically(More)