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- Ramgopal R. Mettu, C. Greg Plaxton
- FOCS
- 2000

We introduce a natural variant of the (metric uncapac-itated)-median problem that we call the online median problem. Whereas the-median problem involves optimizing the simultaneous placement of facilities, the on-line median problem imposes the following additional constraints: the facilities are placed one at a time; a facility cannot be moved once it is… (More)

We describe an efficient algorithm for protein backbone structure determination from solution Nuclear Magnetic Resonance (NMR) data. A key feature of our algorithm is that it finds the conformation and orientation of secondary structure elements as well as the global fold in polynomial time. This is the first polynomial-time algorithm for de novo… (More)

- Ramgopal R. Mettu, C. Greg Plaxton
- Machine Learning
- 2002

Clustering is a fundamental problem in unsupervised learning, and has been studied widely both as a problem of learning mixture models and as an optimization problem. In this paper, we study clustering with respect to the k-median objective function, a natural formulation of clustering in which we attempt to minimize the average distance to cluster centers.… (More)

- Matthew D. Segall, Edmund J. Champness, Chris Leeding, Ryan H. Lilien, Ramgopal R. Mettu, Brian W. Stevens
- Journal of Chemical Information and Modeling
- 2011

In this article we describe a computational method that automatically generates chemically relevant compound ideas from an initial molecule, closely integrated with in silico models, and a probabilistic scoring algorithm to highlight the compound ideas most likely to satisfy a user-defined profile of required properties. The new compound ideas are generated… (More)

Motivated by stochastic systems in which observed evidence and conditional dependencies between states of the network change over time, and certain quantities of interest (marginal distributions, likelihood estimates etc.) must be updated, we study the problem of adaptive inference in tree-structured Bayesian networks. We describe an algorithm for adaptive… (More)

Many algorithms and applications involve repeatedly solving variations of the same inference problem; for example we may want to introduce new evidence to the model or perform updates to conditional dependencies. The goal of adap-tive inference is to take advantage of what is preserved in the model and perform inference more rapidly than from scratch. In… (More)

- Lincong Wang, Ramgopal R. Mettu, Bruce Randall Donald
- 2005 IEEE Computational Systems Bioinformatics…
- 2005

Our paper describes the first provably-efficient algorithm for determining protein structures de novo, solely from experimental data. We show how the global nature of a certain kind of NMR data provides quantifiable complexity-theoretic benefits, allowing us to classify our algorithm as running in polynomial time. While our algorithm uses NMR data as input,… (More)

SUMMARY
We cast the problem of identifying protein-protein interfaces, using only unassigned NMR spectra, into a geometric clustering problem. Identifying protein-protein interfaces is critical to understanding inter- and intra-cellular communication, and NMR allows the study of protein interaction in solution. However it is often the case that NMR studies… (More)

- Özgür Sümer, Umut A. Acar, Alexander T. Ihler, Ramgopal R. Mettu
- Journal of Machine Learning Research
- 2011

Many algorithms and applications involve repeatedly solving variations of the same inference problem , for example to introduce new evidence to the model or to change conditional dependencies. As the model is updated, the goal of adaptive inference is to take advantage of previously computed quantities to perform inference more rapidly than from scratch. In… (More)