Ramesh A. Shivdasani

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Mounting evidence suggests that malignant tumors are initiated and maintained by a subpopulation of cancerous cells with biological properties similar to those of normal stem cells. However, descriptions of stem-like gene and pathway signatures in cancers are inconsistent across experimental systems. Driven by a need to improve our understanding of(More)
In the past 25 years, research has elucidated molecular mechanisms directing key aspects of tumor cell behavior. Detailed understanding of these mechanisms has already changed methods for diagnosis, prognosis, and treatment. With continuing advances in cancer science and the emergence of new technologies for applying basic science to clinical practice, new(More)
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