Ramasubbu Jeyanthi

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The physico-chemical properties of biodegradable polylactide-co-glycolide (PLGA) microspheres containing the peptide salmon calcitonin (sCT) were affected by the processing parameters. The microsphere size increased with an increase in the viscosity of the polymer solution. Concentration of methanol and peptide in the dispersed phase had the most(More)
Purpose. The interaction of salmon calcitonin (sCT) and poly (d,l-lactide-co-glycolide) was detected during preparation and evaluation of microspheres. The purpose of this study was to quantitate the extent and nature of the interaction. Methods. Blank microspheres were prepared by an aqueous emulsification solvent extraction technique. Adsorption studies(More)
Synthetic biodegradable polymers of lactic and glycolic acid have been extensively investigated for sustained drug delivery. Drug release from lactide/glycolide polymers can be either diffusion controlled or matrix erosion controlled. Polymer degradation was dependent on the molecular weight of the polymer and matrix structure of the delivery system. High(More)
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