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Clinical aspects of urea cycle dysfunction and altered brain energy metabolism on modulation of glutamate receptors and transporters in acute and chronic hyperammonemia.
In living organisms, nitrogen arise primarily as ammonia (NH3) and ammonium (NH4(+)), which is a main component of the nucleic acid pool and proteins. Although nitrogen is essential for growth andExpand
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Neuroprotective effect of chrysin on hyperammonemia mediated neuroinflammatory responses and altered expression of astrocytic protein in the hippocampus.
Neuroinflammation is an innate immune response in the central nervous system (CNS) against metabolic and pathogenic toxic wastes. The main hypothesis implies that a state of hyperammonemia which isExpand
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Effect of naringin on ammonium chloride-induced hyperammonemic rats: A dose-dependent study
Abstract Introduction In mammals, ammonia is primarily a toxin that affects the central nervous system, leading to liver damage and urea cycle disorder. Increased accumulation of ammonia results in aExpand
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Molecular docking studies of natural compounds of naringin on enzymes involved in the urea cycle pathway in hyperammonemia
Purpose: To investigate the anti-hyperammonemic activity of naringin by molecular docking via in silico studies.Methods: Urea cycle proteins were docked to the natural compound naringin as well as aExpand