Ramadan Abdou Saleh

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OBJECTIVE To summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction. DESIGN Review of literature. SETTING Fertility research center and obstetrics and gynecology department in a tertiary care facility. RESULT(S) ROS plays an essential role in the pathogenesis of many reproductive processes. In male-factor(More)
OBJECTIVE To examine the effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Prospective study. SETTINGS Infertility clinic at a tertiary care academic institution. PATIENT(S) Ninety-two infertile men with normal female partners. Sixteen fertile donors served as the control(More)
OBJECTIVE To examine levels of sperm DNA damage and oxidative stress (OS) in infertile men with varicocele. DESIGN Prospective controlled study. SETTING Male infertility clinic, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio. PATIENT(S) Thirty-one infertility patients and 16 fertile controls. INTERVENTION(S) Sperm DNA(More)
OBJECTIVE To investigate levels of seminal oxidative stress (OS) and sperm quality in a group of infertile men with a history of cigarette smoking. DESIGN A prospective clinical study. SETTING Male infertility clinic, Urological Institute, the Cleveland Clinic Foundation, Cleveland, Ohio. PATIENT(S) Infertile men who smoked cigarettes (n = 20),(More)
Extensive research in our center at the Cleveland Clinic indicates that the seminal oxidative stress test has diagnostic and prognostic capabilities beyond those of conventional tests of sperm quality or functions. An oxidative stress test can accurately discriminate between fertile and infertile men and identify patients with a clinical diagnosis of(More)
OBJECTIVE To evaluate levels of sperm nuclear DNA damage in infertile men with normal and abnormal standard semen parameters. DESIGN Prospective study. SETTING Male infertility clinic. PATIENT(S) Ninety-two men seeking infertility treatment and 16 fertile volunteers. INTERVENTION(S) Standard semen analysis was performed according to the World Health(More)
Interest in the physiologic and pathologic effects of ROS on male fertility is growing. The controlled generation of very low amounts of ROS seems to regulate the acquisition of sperm-fertilizing ability. High levels of ROS endanger sperm function and viability. Oxidative stress can arise as a consequence of excessive production of ROS or impaired(More)
OBJECTIVE To determine DNA damage as measured by the sperm chromatin structure assay (SCSA) in subsets of human spermatozoa at different stages of maturation in patients who are undergoing infertility evaluation. DESIGN Prospective study. SETTING Andrology laboratory at a tertiary care hospital. PATIENT(S) Fifty-six patients undergoing infertility(More)
OBJECTIVE To examine the relationship between sperm reactive oxygen species (ROS) production and sperm morphology in a group of infertile men and healthy fertile donors. DESIGN A prospective clinical study. SETTING Male infertility clinic, Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, and the Reproductive Medicine(More)
To investigate the role of increased seminal leukocytes in enhancing reactive oxygen species (ROS) production by human spermatozoa.A prospective study. Male infertility clinic.Forty-eight infertile men. Standard semen analysis. Assessment of sperm nuclear DNA damage by sperm chromatin structure assay. Incubation of spermatozoa from nonleukocytospermic(More)