Ramachandran Meenakshisundaram

Learn More
BACKGROUND Snake and insect venoms have been demonstrated to have beneficial effects in the treatment of certain diseases including drug resistant human immunodeficiency virus (HIV) infection. We evaluated and hypothesized the probable mechanisms of venoms against HIV. METHODS Previous literatures published over a period of 30 years (1979-2009) were(More)
not just a surrogate for serosal effusions? Int J Cardiol Feb 3 2010;146(3):473–4. [10] Turgut O, Tandogan I, Yilmaz MB, Gul I, Zorlu A. CA125 in heart failure: implications for immunoinflammatory activity. Int J Cardiol Jan 7 2011;146(1):99–100. [11] Kosar F, Aksoy Y, Ozguntekin G, Ozerol I, Varol E. Relationship between cytokines and tumour markers in(More)
OBJECTIVES The objectives were to investigate into the relationship between lipid profile including Apolipoprotein-A1 (Apo-A1) and Apolipoprotein-B (Apo-B) and smokers and to relate them with smoking pack years. MATERIALS AND METHODS A total of 274 active male smokers without any other illnesses and age matched male healthy control subjects (78) with(More)
Cell cycle regulators play crucial roles in the preadipocyte proliferation and adipocyte differentiation. Cyclin-dependent kinase 4 (CDK4) mediates with D-type cyclins entry of cells into cell cycle in response to external stimuli. CDK4 plays a role in body weight, adipogenesis, and beta cell proliferation. CDK4 null mice develop type 2 diabetes (T2D).(More)
BACKGROUND Coagulopathy after snake bite is well known; however, cardiac tamponade as a manifestation of coagulopathy is rare. OBJECTIVE To report a case of pericardial hemorrhage with cardiac tamponade after Russell viper bite. CASE REPORT A 26-year-old man developed breathlessness after being bitten by a Russell viper. The clinical and laboratory(More)
Resistance of human immunodeficiency virus to antiretroviral therapy is a major concern. As new therapies are few, progress to acquired immune deficiency syndrome will ensue. We report a patient with multidrug-resistant HIV, high viral load, and low CD4 count who took a snake venom preparation while maintained on antiretroviral therapy. The response was(More)
BACKGROUND Type 2 diabetes (T2D) is associated with obesity and has been shown recently to be associated with tumors/cancer. HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. We have previously shown that CHOP 5'UTR-c.279T>C and +nt30C>T haplotype variants contribute to T2D. CHOP deficiency causes obesity in mice, thus CHOP gene(More)
BACKGROUND Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at identifying a role of CDK4 IVS4-nt40 G-->A(More)