The T-cell-specific cell-surface receptors CD28 and CTLA-4 are important regulators of the immune system. CD28 potently enhances those T-cell functions that are essential for an effective antigen-specific immune response, and the homologous CTLA-4 counterbalances the CD28-mediated signals and thus prevents an otherwise fatal overstimulation of the lymphoid… (More)
Insect embryos have been classified as intermediate- and short-germ embryos, in which posterior segments are thought to be generated sequentially from an uncommitted growth zone, or as long-term embryos, such as Drosophila melanogaster, which develop primordia for all segments simultaneously. In Drosophila the coordinated activities among a three-tiered… (More)
The inducible steroid-1-dehydrogenase from the bacterium Rhodococcus erythropolis IMET 7030 was purified to homogeneity using affinity chromatographic, electrophoretic, and ion exchange techniques. The spectrum of the pure enzyme is characterized by the associated FAD. The M(r) of the enzyme is 56,000. The amino acid composition and the sequence of the 13… (More)
A new culturing strategy optimizes functional neuronal development of human neural precursor cells. Spine neck geometry determines spino-dendritic cross-talk in the presence of mobile endogenous calcium binding proteins.
Acknowledgments I am deeply grateful to my advisor, Dr. Si Qing Zheng. He has been very supportive and encouraging during my time as a graduate student. His rigorous research attitude, breadth of knowledge, and innovative ideas have been a great benefit for me to work on my Ph.D research. I would like to give my special thanks to Dr. Donald Kraft for his… (More)