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The T-cell-specific cell-surface receptors CD28 and CTLA-4 are important regulators of the immune system. CD28 potently enhances those T-cell functions that are essential for an effective antigen-specific immune response, and the homologous CTLA-4 counterbalances the CD28-mediated signals and thus prevents an otherwise fatal overstimulation of the lymphoid(More)
Max is the central component of the Myc/Max/Mad network of transcription factors that regulate growth, differentiation and apoptosis. Whereas the Myc and Mad genes and proteins are highly regulated, Max expression is constitutive and no post-translational regulation is known. We have found that Max is targeted during Fas-induced apoptosis. Max is first(More)
Insect embryos have been classified as intermediate- and short-germ embryos, in which posterior segments are thought to be generated sequentially from an uncommitted growth zone, or as long-term embryos, such as Drosophila melanogaster, which develop primordia for all segments simultaneously. In Drosophila the coordinated activities among a three-tiered(More)
Subscribing organizations are encouraged to copy and distribute this table of contents for non-commercial purposes Review The Phox homology (PX) domain, a new player in phosphoinositide signalling NMR structure of bucandin, a neurotoxin from the venom of the Malayan krait (Bungarus candidus) Human kinesin superfamily member 4 is dominantly localized in the(More)
The inducible steroid-1-dehydrogenase from the bacterium Rhodococcus erythropolis IMET 7030 was purified to homogeneity using affinity chromatographic, electrophoretic, and ion exchange techniques. The spectrum of the pure enzyme is characterized by the associated FAD. The M(r) of the enzyme is 56,000. The amino acid composition and the sequence of the 13(More)
Acknowledgments I am deeply grateful to my advisor, Dr. Si Qing Zheng. He has been very supportive and encouraging during my time as a graduate student. His rigorous research attitude, breadth of knowledge, and innovative ideas have been a great benefit for me to work on my Ph.D research. I would like to give my special thanks to Dr. Donald Kraft for his(More)
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