Rama Rao Kalakuntla

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Simvastatin and Ezetimibe are used to treat hyperlipidemia. A simple, precise cost effective and stability indicating RP-HPLC method has been developed and validated for the simultaneous determination of Simvastatin and Ezetimibe in pharmaceutical formulations. Separation of both simvastatin and Ezetimibe was achived with in 5 minutes with required(More)
Bioanalytical method validation includes all of the procedures that demonstrate that a particular method used for a quantitative measurement of analytes in a given biological matrix is selective, sensitive, reliable and reproducible for the intended use. Any method developed for the analysis of analytes in biological fluids must yield consistent results(More)
A selective and sensitive liquid chromatography-tandem mass spectrometric method (LC-MS/MS) has been developed and validated for the quantification of zileuton in human plasma. Deuterated internal standard (zileuton D4) was used as the internal standard (ISTD). Zileuton was extracted by liquid-liquid extraction using methyl tert-butyl ether and separated by(More)
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