Highly Influential Citations20
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Myostatin (MSTN), a transforming growth factor (TGF)-beta superfamily member, has been shown to negatively regulate muscle growth by inhibiting muscle precursor cell proliferation. Here, we stably… Continue Reading
Myostatin is a member of the TGF-beta superfamily that is essential for proper regulation of skeletal muscle growth. As do other TGF-beta superfamily members, myostatin signals into the cell via a… Continue Reading
The ability of both somatostatin (SS) and its stable analogues to inhibit cell growth depends on the stimulation of specific membrane receptors (SSTR1-5), which belong to the G protein-coupled… Continue Reading
The present study was undertaken to examine the mechanistic basis for the recent observation that the pyridine nucleotide derivative 6-aminonicotinamide (6AN, NSC 21206) enhances the accumulation and… Continue Reading
7017 Background: PR1 is a nanomeric HLA-A2-restricted peptide derived from the myeloid leukemia-associated antigens proteinase 3 and neutrophil elastase. Methods: Sixty-six HLA-A2+ patients with ac...
La presente investigacion se llevo a cabo en el Plantel Industrial Lovago (prefabricados de concreto) de la Empresa EICMEP ubicado en el empalme de Lovago. El objetivo principal de esta investigacion… Continue Reading
An asymmetric synthesis of α-spiro-δ-lactam via organocascade reaction from easily accessible starting materials is reported. The catalytic sequence undergoes enantioselective Michael addition of… Continue Reading
We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral… Continue Reading
In this review the principal enantioselective methodologies merging transition-metal catalysis and aminocatalysis are disclosed. 1 Introduction 2 Transition-Metal and Enamine Catalysis 3… Continue Reading