Ralph R. Brown

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The mechanisms that underlie cholinergic neuronal degeneration in Alzheimer disease (AD) are unclear, but recent data suggest that oxidative stress plays a role. We report that 4-hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, damages and kills basal forebrain cholinergic neurons when administered intraparenchymally. Examination of(More)
Edematous responses were induced in the limbs of Sprague-Dawley rats by intravenous, intraperitoneal, or intra-articular injections of group-specific polysaccharide (PS) isolated from the cell walls of group A streptococci. After intravenous injection of the edema-producing PS, vascular permeability increase (measured by 125I-human serum albumin) was(More)
Single units in the nervous system frequently exhibit spikelike discharges in the absense of any controllable stimulation presented externally to the organism. The nature of these "spontaneous" discharges suggests that statistical descriptions might well reveal some basic properties of the units. In recent studies of the cochlear nucleus we have encountered(More)
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