Ralph L. Sacco

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BACKGROUND Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with(More)
BACKGROUND Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a(More)
Donald Lloyd-Jones, MD, ScM, FAHA; Robert Adams, MD, FAHA; Mercedes Carnethon, PhD, FAHA; Giovanni De Simone, MD; T. Bruce Ferguson, MD; Katherine Flegal, PhD*; Earl Ford, MD, MPH*; Karen Furie, MD; Alan Go, MD; Kurt Greenlund, PhD*; Nancy Haase; Susan Hailpern, DPH; Michael Ho, MD, PhD; Virginia Howard, PhD, FAHA; Brett Kissela, MD; Steven Kittner, MD;(More)
Donald Lloyd-Jones, MD, ScM, FAHA; Robert J. Adams, MD, FAHA; Todd M. Brown, MD; Mercedes Carnethon, PhD, FAHA; Shifan Dai, MD, PhD*; Giovanni De Simone, MD; T. Bruce Ferguson, MD; Earl Ford, MD, MPH*; Karen Furie, MD; Cathleen Gillespie; Alan Go, MD; Kurt Greenlund, PhD*; Nancy Haase; Susan Hailpern, DPH; P. Michael Ho, MD, PhD; Virginia Howard, PhD, FAHA;(More)
BACKGROUND Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional(More)
BACKGROUND The contribution of various risk factors to the burden of stroke worldwide is unknown, particularly in countries of low and middle income. We aimed to establish the association of known and emerging risk factors with stroke and its primary subtypes, assess the contribution of these risk factors to the burden of stroke, and explore the differences(More)
BACKGROUND AND PURPOSE The aim of this investigation was to determine the importance of race as a determinant of intracranial atherosclerotic stroke in a community-based stroke sample. METHODS Residents from northern Manhattan over age 39 years hospitalized for acute ischemic stroke (n = 438, black 35%, Hispanic 46%, white 19%) were prospectively(More)
The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the prevention of ischemic stroke among survivors of ischemic stroke or transient ischemic attack. Evidence-based recommendations are included for the control of risk factors, interventional approaches for atherosclerotic disease, antithrombotic treatments(More)
The aim of this updated statement is to provide comprehensive and timely evidence-based recommendations on the prevention of ischemic stroke among survivors of ischemic stroke or transient ischemic attack. Evidence-based recommendations are included for the control of risk factors, interventional approaches for atherosclerotic disease, antithrombotic(More)