Ralph Jackson

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BACKGROUND Current thinking, which is based mainly on rodent studies, is that physiologic doses of folic acid (pterylmonoglutamic acid), such as dietary vitamin folates, are biotransformed in the intestinal mucosa and transferred to the portal vein as the natural circulating plasma folate, 5-methyltetrahydrofolic acid (5-MTHF) before entering the liver and(More)
AIMS To characterize the pharmacology of MEDI0382, a peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptors. MATERIALS AND METHODS MEDI0382 was evaluated in vitro for its ability to stimulate cAMP accumulation in cell lines expressing transfected recombinant or endogenous GLP-1 or glucagon receptors, to potentiate(More)
We measured the concentration of oxytocin and vasopressin in microdissected areas of the hypothalamus and posterior pituitary in weanling and adult female rats. Oxytocin concentration was significantly less in adult rats as compared to weanling rats in the supraoptic nucleus, median eminence, and retrochiasmatic area with no significant differences in(More)
The relationship of P to Aetius, however, is not satisfactorily resolved. There is no clear line on what to do with passages in P suspected of being interpolated from Aetius. Some are banished completely from both text and apparatus; others are relegated to an appendix; still others are included in the text but in smaller letters. It would perhaps have been(More)
"realistic" representation occurred and had meaning. None the less, in bringing all this material together and to the attention of medical historians, in offering a rigorous discussion of the opportunities and problems it represents, and careful analysis of many individual items, the authors have certainly done all those interested in health and disease in(More)
These meticulously produced volumes will be of great interest to medical historians working on France and also to those concerned with theories of mind-body interaction. Each book has a short introduction explaining the origins and main contents of the work that follows. The texts themselves, prepared from manuscripts, show all relevant variants. The(More)
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