Ralph Elliott

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ViSiCAST is a major new project funded by the European Union, aiming to provide improved access to services and facilities for deaf citizens through sign language presented by a virtual human, or avatar. We give here an outline of the project, and describe early work in the area of linguistics and language processing. This work covers two distinct but(More)
Sign languages are the native languages for many pre-lingually deaf people and must be treated as genuine natural languages worthy of academic study in their own right. For such pre-lingually deaf, whose familiarity with their local spoken language is that of a second language learner, written text is much less useful than is commonly thought. This paper(More)
The PPM1D gene is aberrantly amplified in a range of common cancers and encodes a protein phosphatase that is a potential therapeutic target. However, the issue of whether inhibition of PPM1D in human tumour cells that overexpress this protein compromises their viability has not yet been fully addressed. We show here, using an RNA interference (RNAi)(More)
We present an overview of research at UEA into the animation of sign language using a gesture notation, outlining applications that have been developed and key aspects of the implementation. We argue that the requirements for virtual human signing involve the development of expressive characters. Although the principal focus of work has been on sign(More)
Many deaf people rely on sign language as their primary mode of communication. They will enjoy enhanced information access if media applications can provide signed commentaries, The advent of multimedia makes such provision possible. We outline here a prototype real-time subtitle-tosigning translation system, based on the adaptation and integration of(More)
We describe a prototype Search-by-Example or look-up tool for signs, based on a newly developed 1000-concept sign lexicon for four national sign languages (GSL, DGS, LSF, BSL), which includes a spoken language gloss, a HamNoSys description, and a video for each sign. The look-up tool combines an interactive sign recognition system, supported by(More)
The B6C3F1 mouse is used worldwide to gauge the carcinogenic hazard posed by chemicals to humans. An assessment of the ability of this rodent model to predict human neoplasia requires an evaluation of similarities and differences in the genetics of tumor formation between these two species. We examined 142 spontaneous and chemically-induced liver tumors(More)
Excision repair cross-complementation group 1 (ERCC1) is a DNA repair enzyme that is frequently defective in non-small cell lung cancer (NSCLC). Although low ERCC1 expression correlates with platinum sensitivity, the clinical effectiveness of platinum therapy is limited, highlighting the need for alternative treatment strategies. To discover new(More)
In February 1999, Benoit Mandelbrot submitted an article to Scientific American called ”A Multifractal Walk down Wall Street.” In it, he discusses how fractal geometry can be used to model the stock market curves. In the following months several letters to the editor appeared claiming that Mandelbrot had plagiarized the work of the economist Ralph Nelson(More)