Ralph E. Bertermann

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Prostaglandin F2 alpha (PGF2 alpha) has recently been implicated in the pathogenesis of some diarrhea in man. PGF2 alpha has been shown to increase the smooth muscle contractile motility of some gastrointestinal muscles in vitro. The in vivo effects of PGF2 alpha on bowel smooth muscles are not clearly delineated. The aim of this study was to investigate(More)
The mechanism of the gastrointestinal motility effects of diphenoxylate and morphine in preventing E prostaglandin (PG) diarrhea was investigated. Duodenal motility studies were conducted in the anesthetized dog. Two contractile force transducers were oriented to record contractions from both the circular and longitudinal muscles. In some experiments the(More)
Measurement of the gastric transmucosal potential difference (PD) was used to study the effect of gastric antisecretory prostaglandins on the integrity of the gastric mucosa of the Heidenhain pouch dog. Intragastric administration of SC-29333 [(±)-15-deoxy-16-α,β-hydroxy-16-methyl PGE1 methyl ester] slightly but significantly increased the transmucosal PD(More)
The instrumentation of a tablet breaking-strength tester, for the automatic recording of hardness values, is described. A comparison is made between a computerized hardness tester and another identical model hardness tester from the same manufacturer ("standard"). Three lots of placebo tablets at different hardness values were compared. No significant(More)
The potential role of endogenous opiates in the mediation of the diarrheal actions of prostaglandin-F2 alpha (PGF2 alpha), 5-hydroxytryptophan (5-HTP) and methacholine was investigated. The interaction of the antidiarrheal agents morphine, propantheline bromide and cyproheptadine on the course of PGF2 alpha-induced diarrhea in mice was studied, as were the(More)
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