Ralph Brinks

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This paper descibes a new method for deriving incidence rates of a chronic disease from prevalence data. It is based on a new ordinary differential equation, which relates the change in the age-specific prevalence to the agespecific incidence and mortality rates. The method allows the extraction of longtudinal information from cross-sectional studies.(More)
With great interest we read the recently published article about prevalence and incidence of diabetes in Samoa by Lin et al. (2017). The authors used a sequence of cross-sections to first estimate the prevalence and then derived the incidence from these prevalence data. For this, they used a method published by Styblo et al. (1969). We thank the authors for(More)
Respiratory gating is a helpful technique to reduce motion blur in PET images of the lungs. Efforts still need to be made on reconstruction schemes adapted to this kind of data, since gated data are usually of low statistical quality. A 4D joint- estimation image reconstruction method is tested and compared to classic OSEM algorithms on list-mode data(More)
BACKGROUND Age of onset is an important outcome to characterize a population with a chronic disease. With respect to social, cognitive, and physical aspects for patients and families, dementia is especially burdensome. In Germany, like in many other countries, it is highly prevalent in the older population and imposes enormous efforts for caregivers and(More)
We derive a partial differential equation (PDE) that models the age-specific prevalence of a disease as a function of the incidence, remission and mortality rates. The main focus is on non-communicable diseases (NCDs), although the PDE is not restricted to NCDs. As an application of the PDE, the number of persons with dementia in Germany until the year 2050(More)
BACKGROUND The database of the German Institute of Medical Documentation and Information makes it possible for the first time to compute statistics on diabetes for all insurees of the statutory health insurance scheme in Germany. Data from this comprehensive source are less likely to be biased by differences in the membership structures of individual(More)
BACKGROUND Estimation of incidence of the state of undiagnosed chronic disease provides a crucial missing link for the monitoring of chronic disease epidemics and determining the degree to which changes in prevalence are affected or biased by detection. METHODS We developed a four-part compartment model for undiagnosed cases of irreversible chronic(More)
Die Prävalenz des Typ-2-Diabetes mellitus (T2DM) nimmt weltweit zu. Die Erkrankung hat wegen ihrer individuellen und sozialen Belastungen hohe gesundheitswissenschaftliche Relevanz. Es konnte gezeigt werden, dass bei Patienten mit einer prädiabetischen Situation die Manifestation des T2DM durch geeignete Präventionsmaßnahmen (medikamentöse Interventionen,(More)
Dementia is becoming a major health burden, which is mainly due to the increasing life expectancy in many developed countries. To describe the disease progression of individuals, multistate models are generally appropriate tools. These models allow the individuals to move along a path consisting of a finite number of disease states. We consider a(More)