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The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division.
During asymmetric cell division, the mitotic spindle must be properly oriented to ensure the asymmetric segregation of cell fate determinants into only one of the two daughter cells. In DrosophilaExpand
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Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage
Drosophila neuroblasts and ovarian stem cells are well characterized models for stem cell biology. In both cell types, one daughter cell self-renews continuously while the other undergoes a limitedExpand
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Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi
Summary The balance between stem cell self-renewal and differentiation is precisely controlled to ensure tissue homeostasis and prevent tumorigenesis. Here we use genome-wide transgenic RNAi toExpand
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Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer.
Cell division is commonly thought to involve the equal distribution of cellular components into the two daughter cells. During many cell divisions, however, proteins, membrane compartments,Expand
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RNAi screening comes of age: improved techniques and complementary approaches
Gene silencing through sequence-specific targeting of mRNAs by RNAi has enabled genome-wide functional screens in cultured cells and in vivo in model organisms. These screens have resulted in theExpand
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Genome-wide RNAi screen identifies networks involved in intestinal stem cell regulation in Drosophila.
The intestinal epithelium is the most rapidly self-renewing tissue in adult animals and maintained by intestinal stem cells (ISCs) in both Drosophila and mammals. To comprehensively identify genesExpand
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A regulatory network of Drosophila germline stem cell self-renewal.
Stem cells possess the capacity to generate two cells of distinct fate upon division: one cell retaining stem cell identity and the other cell destined to differentiate. These cell fates areExpand
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Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses
Loss-of-function analyses in yeast and flies identify molecular complexes that regulate ribosomal DNA transcription. Regulating Nucleolar Size The higher proliferation rate of cancer cells requiresExpand
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Integrating protein-protein interaction networks with phenotypes reveals signs of interactions
A major objective of systems biology is to organize molecular interactions as networks and to characterize information flow within networks. We describe a computational framework to integrateExpand
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Systematic screen of chemotherapeutics in Drosophila stem cell tumors
Significance In this article we report a large-scale chemical screen in adult Drosophila to find inhibitors of stem-cell–derived tumors. To our surprise, we found that some Food and DrugExpand
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