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Tensile Forces Originating from Cancer Spheroids Facilitate Tumor Invasion
A tension-based model is proposed to explain the collagen organization and the onset of invasion by forces originating from the tumor, and results suggest that tensile forces in the ECM facilitate invasion.
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting
A theoretical model is provided that describes the physical basis of one-dimensional wetting and shows that this mechanism occurs in model membranes interacting with nanofibers, and in human cells interacting with extracellular matrix meshworks.
Cancer cells in the tumor core exhibit spatially coordinated migration patterns
Tissue explant imaging reveals that cancer cells in the tumor core migrate in a coordinated manner that is actively driven by the actin cytoskeleton.
Cell Migration in Tissues: Explant Culture and Live Imaging.
A method for long-term 3D imaging of tissue explants by two-photon excitation microscopy is described, which can help understand dynamic behavior of cells in homeostasis and disease, and would be applicable to various tissues.
A new biomimetic assay reveals the temporal role of matrix stiffening in cancer cell invasion
The findings demonstrate that, depending on the timing of its stiffening, the extracellular matrix could either inhibit or promote cancer cell invasion and subsequent metastasis: while matrix stiffening after the onset of invasion promotes cancer cell migration and tumor spreading, stiff matrices encapsulate the tumor at an early stage and prevent cancer cell Invasion.
First person – Ralitza Staneva
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside
Adhesion to nanofibers drives cell membrane remodeling through 1D wetting
It is shown that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a novel physical mechanism the authors term “ onedimensional” membrane wetting, which is a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted byMeningococcus during infection.